Moreover, due to the functional analogy, it should be interesting to study whether the CaMKK/CaMK1 axis regulates NFAT expression in addition to CaMKII in pathologies such as Alzheimer's disease, muscular hypertrophy or cancer progression and metastasis, where hyperactivation of NFAT has been detected (53,55,64–66). Here, CAMK2G is linked to early-onset autosomal dominant Alzheimer disease.