This observation could be in line with other studies which, by using mouse models with affected NADPH oxidase function (e.g. gp91phox and p47phox knock-out mice), showed an increased severity of T-cell mediated immune diseases, such as arthritis and experimental autoimmune encephalomyelitis [30]–[32]. The gene discussed is FMO5; the disease is experimental autoimmune encephalomyelitis.