NZ-1 and its rat-human chimeric anti-podoplanin antibody (NZ-8) possess antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) functions against podoplanin-expressing glioblastoma or malignant mesothelioma cell lines16, 26. The gene discussed is PDPN; the disease is glioblastoma.