Moreover, the activation of TREK-1 channels was demonstrated to be beneficial in different functions such as general anesthesia, neuroprotection by the way of polyunsaturated fatty acids, pain, ischemia, and epilepsy (Alloui et al. 2006; Heurteaux et al. 2006a; Lauritzen et al. 2000; Noel et al. 2009). Here, KCNK2 is linked to epilepsy.