Among these 23 curated AD-related genes, the allelic effects for APOE, GAB2, SASH1, and FAM113B related genotypes on AD risk were replicated in the HBTRC samples, with the most likely reason for lack of replication of other reported risk variants being lack of power in our relatively small study group (Supplementary Table S2). This evidence concerns the gene APOE and Alzheimer disease.