When considering only disrupted pairs common to both AD and HD, the top 10 hub genes in this shared DC network were RNASE1, GSN, SLC39A11, GPS2, CSRP1, FAM59B, TIMELESS, EZR, AMPD2, and SASH1, six of which were also in the top 10 hub genes for AD (Supplementary Fig S5A–C). Here, EZR is linked to Alzheimer disease.