LOC interactions of genes at the interface between different DC modules also revealed new candidate disease genes like FAM59B. Finally, our systematic search for physical interactions mediating the common DC pairs between AD and HD, besides revealing extensive molecular alterations involving genes such as GSN and SOX10 related to oligodendrocyte differentiation, revealed an interesting split of GOC and LOC dysregulation, respectively, of two physically inter-connected cellular processes, chromatin organization and neural differentiation. Here, GAREM2 is linked to Alzheimer disease.