For instance, the subnetwork contains 3 AD GWAS or OMIM genes (APOE, PSEN1, and BIN1, P = 0.0029) and significantly overlaps with genes known to be upregulated in brain samples from AD patients (Blalock et al, 2004) (P = 9.5 × 10−12). Here, APOE is linked to Alzheimer disease.