When comparing siRNA candidates that suppress HTT toxicity in a HD model (Miller et al, 2012), seven of the 147 siRNA candidates represented on our expression microarray (ASGR1, CAPN2, DAXX, FABP5, RAP1A, RNF130, and TRPV6) mapped to the subnetwork (P = 0.0027). Here, RNF130 is linked to Huntington disease.