Among 25 networks identified, one was centered by viral infection in adults (Figure 6) and contains both up- and down- regulated genes that are involved in pathways related to host defense responses such as oxidative phosphorylation, ABC transporter, endocytosis, phagocytosis, TGF-beta signaling pathway, mTOR signaling pathway, MAPK signaling pathway, JAK-STAT pathway, and lysosome. Here, ABCG2 is linked to viral infectious disease.