As published earlier, in the cohort from Israel, we were able to detect reduced blood levels of the PP13 protein in the first trimester in 85% of the cases and 15% of the controls [25], and also found reduced PP13 RNA in the placenta of all preeclampsia cases near the time of delivery [20], and in 30% in the first trimester (Sammar et al., unpublished results). Here, LGALS13 is linked to preeclampsia.