ESR1 and breast carcinoma: - Required for cancer cell proliferation in vitro. - Required for cancer cell migration in vitro and tumor metastasis in a mouse xenograft model. - Waixenicin A, TRPM7 blocker, inhibits growth and survival of breast cancer cells MCF-7. - TRPM7 involved in estrogen receptor-negative metastatic breast cancer cells migration through kinase domain. - Involved in ginsenoside Rd-induced apoptosis in cells. - Involved in epithelial mesenchymal transition. - TRPM7 mediates migration and invasion of breast cancer cells (MDA-MB-435) involving phosphorylation of Src and MAPK.