TRPM7 and Hyperglycemia: - Silencing TRPM7 promotes growth/proliferation and nitric oxide production viaERK in human umbilical vein vascular endothelial cells (HUVECs). - Silencing TRPM7 inhibits growth and migration of human microvascular endothelial cells (HMEC) but stimulates growth of HUVECs, partly because of impaired phosphorylation of ERK in HMEC. - Inhibition of TRPM7 leads to increased cell growth and migration in HUVECs. - TRPM7 contributes to hyperglycemia-induced injury of HUVECs.