[30]. B. burgdorferi lacking DbpA and DbpB in fact exhibited both reduced colonization and dissemination activity and a three- to four-log increase in ID50, indicating that these adhesins play a significant role in infection [31]–[35]. Consistent with this role, dbpA and dbpB are expressed efficiently in culture conditions that may reflect the host environment, such as at mammalian body temperature or in the presence of atmospheric CO2[36]–[38]. The gene discussed is YBX1; the disease is infection.