Taking together, our results show that two different EHMT1- and EHMT2-specific chemical inhibitors, as well as knocking down the expression of either EHMT1 or EHMT2 enhance interferon response in CML cell lines, implying that inhibition of EHMT1 and EHMT2 sensitizes interferon resistant CML cell lines to interferon-mediated anti-proliferation. The gene discussed is EHMT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.