EHMT2 and chronic myelogenous leukemia, BCR-ABL1 positive: To test if inhibition of EHMT1 and EHMT2 in CML cells enhances their response to interferon, we treated K562 cells, a CML cell line, with an EHMT1 and EHMT2 specific inhibitor, BIX01294 [6], [10], and measured the expression of ISGs with RT-qPCR.