Two other genes that were upregulated in our analysis by hypoglycaemia were EPHA2 and NEDD4L. EPHA2 is a transmembrane receptor tyrosine kinase, which is overexpressed in many carcinomas, including early stage colorectal cancer [52], and its expression is highly correlated to tumour invasion and metastasis [53]. This evidence concerns the gene NEDD4L and colorectal cancer.