Taken together, our studies establish two new, highly versatile human MUC1- expressing mouse models of Kras- and Pten- induced oviductal and endometrial cancers with endometrioid histology, which closely mirror the pathology and immunogenicity of human disease, and demonstrate the influence of the tumor microenvironment on gynecological cancer development. The gene discussed is PTEN; the disease is endometrial cancer.