To investigate whether MMP-2 and MMP-7 were up-regulated by ATF4 in vivo, we performed immunohistochemistry in the metastatic tumors that had been injected with the TE-1LM-ATF4, TE-1HM-SCR, and TE-1HM-siATF4 cells. Here, MMP2 is linked to metastatic neoplasm.