Those mice showed severe brown lipoatrophy, obesity, hypoinsulinemia, mild fasting hyperglycemia, glucose intolerance, vascular dysfunction, macrophage infiltration, oxidative stress, and a significant increase of gene markers of endothelial activation and inflammation as previously characterized [23], TNF-α playing a major role [23]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.