TIMP1 and breast cancer: Interestingly, the up-regulation of Jun TF in MCF7 is connected to the activation of TIMP1, a mettallopeptidase inhibitor whose overexpression contributes to antimetastatic effect in BC [66], and to the activation of NQO1 (NADPH quinone oxidoreductase 1), playing a cytoprotective role and found associated to increase cell-sensitivity to BC anticancer treatment [67].