Then, evidence includes XPC that plays a central role in the recognition of DNA damage; LIG3 which is involved in excision repair; TDG which is important in DNA demethylation via the base excision repair pathway [51], in cellular defense against genetic mutation, in regulation of the epigenome and gene expression in non-melanoma skin cancer [52]; MUTYH that is involved in oxidative DNA damage repair in mammalian cells [53]. This evidence concerns the gene LIG3 and non-melanoma skin carcinoma.