EZH2 and hereditary clear cell renal cell carcinoma: An important up-regulated gene in the A375 cell line is EZH2 (Enhancer of zeste homolog 2), a member of polycomb protein and a part of polycomb repressive complex, implicated in cancer stem cell maintenance and metastasis in breast and pancreatic cancer [77,78], and it could be considered as a prognostic marker in renal cell carcinoma [79].