With respect to the 18 insertions and 15 deletions reported in Mitomap, some of them are associated to cancer or other diseases, i.e. a set of D-loop mutations (m.514insCG found in head/neck tumor, m.568insC(n) found in multiple tumor types, m.16189insT found in bladder tumor, m.310delT found in breast tumor), three indels events in the mitochondrial gene encoding 12S rRNA, MT-RNR1, (m.956insC, m.956delC, m.960delC, which are possibly DEAF-associated) and one deletion in the gene encoding for tRNA threonine, MT-TT, (m.15940delT found in multiple myeloma) [17]. The gene discussed is MT-RNR1; the disease is AL amyloidosis.