Recent multidimensional studies of DIPG tumors confirmed a global landscape of DNA hypomethylation seen in K27M-mutant DIPG tumors, and showed distinct subgrouping of tumors with activated Hedgehog (Hh) or N-Myc (MYCN) seen by corroborative transcriptomic and proteomic studies [60]. Here, MYCN is linked to diffuse intrinsic pontine glioma.