CLEC4C and HIV-1 infection: In order to delineate the role of human pDC in HIV-1 infection and pathogenesis in vivo, we developed and screened a number of pDC-reactive monoclonal antibodies (mAb) and identified an anti-BDCA2 (CD303) mAb (15B), which could specifically deplete human pDC in lymphoid organs in humanized mice.