P2RY1 and Cerebral ischemia: P2Y1 antagonists applied in a rat model of cerebral ischemia reduced the infarct volume and improved motor function recovery.68 In contrast, neuroprotective effects of P2Y1-mediated signaling in brain astrocytes under various pathological conditions have been reported.69, 70, 71 Further research is required to determine — and to separate — the beneficial and detrimental effects of P2Y1-mediated signaling in the ischemic brain and retina.