ANGPTL2 and cancer: Angptl2 is expressed in the heart, adipose tissue, stomach, small intestine, colon, ovary, uterus, spleen, striated muscle, and, at lower levels, in other tissues (Kim et al. 1999; Tabata et al. 2009) and Angptl2 is secreted by different cell types such as adipocytes (Tabata et al. 2009), endothelial cells (Farhat et al. 2013), macrophages (Tazume et al. 2012), keratinocytes (Ogata et al. 2012) and cancer cells (Endo et al. 2012).