The group lead by M. Gilliet demonstrated that pDC-derived IFN is essential for the development of psoriasis [77]; moreover, antimicrobial peptide LL-37 within the psoriatic skin can complex with self-nucleic acids and deliver them to pDCs to engage TLR7/9 and induce IFN production [78] (Figure 1). This evidence concerns the gene IFNA1 and psoriasis.