ITGAE and rheumatoid arthritis: Whereas CD103+ DCs in the intestine convert dietary vitamin A to RA that induces expression of the intestinal homing receptors α4β7 integrin and CCR9 on responding T cells (116), skin DCs can convert sunlight-derived vitamin D into the active 1,25(OH)2D3 form, which induces T cell expression of CCR10, the receptor for the epithelial chemokine CCL27 that is produced in abundance by skin keratinocytes (117).