A significant loss of E-cadherin gene expression and an increase in vimentin gene expression was seen in the BRAFV600E thyroid tumors compared to normal thyroid (Figure 2A) and similar data were obtained by immunohistochemistry where vimentin staining was highly positive only in BRAFV600E tumor specimens (Figures 2B–E). The gene discussed is CDH1; the disease is neoplasm.