GSTP1 and hepatocellular carcinoma: Bakker et al. (2002) initially showed that methyl-CpG binding domain protein (MBD)2 represses transcription from hypermethylated GSTP1 gene promoters in HCC cells connecting hypermethylation and reduced transactivation potential. Similarly, Lin and Nelson (2003) published that MDB2 mediates transcriptional repression associated with hypermethylated GSTP1 CGIs in MCF-7 breast cancer cells.