MMP14 and neoplasm: Further, MMP-14 is abundantly expressed by hepatocytes and studies of CD147 regulation of MMP-14 in tumour cells have found that a feedback loop exists, whereby MMP-14 cleaves CD147 from the cell surface to produce soluble CD147 ligand, which results in an autocrine regulation of the expression of both MMP-14 and CD147 [66], [67].