TGM2 and autoimmune disease: Due to the crucial involvement of the idiotypic network in the autoimmune diseases and the promising therapeutic applications, the detailed model we present for Ab2-AIM2 and for its interaction with Ab1-MB2.8 could be the basis for new possible therapeutic strategies, such as the design of humanized antibodies for the inhibition of TG2 binding by autoantibodies in celiac disease.