Following our finding that (±)-marinopyrrole A (1) antagonizes Mcl-1 and overcomes resistance of human cancer cells to the Bcl-xL antagonist ABT-737 [10], we recently reported a series of novel cyclic marinopyrroles as disruptors of protein-protein interactions between the pro-apoptotic protein, Bim, and the pro-survival proteins, Bcl-xL and Mcl-1 [16]. This evidence concerns the gene MCL1 and cancer.