In this study, we found that the rs1952438 in the suppressors of cytokine signaling (SOCS4) gene, rs2289278 in the thymic stromal lymphopoietin (TSLP) gene and rs2074724 in the hepatocyte growth factor (HGF) gene were highly associated with a poor prognosis of breast cancer. The gene discussed is SOCS4; the disease is breast cancer.