PPARA and obesity due to melanocortin 4 receptor deficiency: NCOA1, one of the most significant gene found for all fatty acids ratios, is involved in the mechanism of gene regulation by peroxisome proliferators via PPARα, a master gene whose regulation is altered in obesity.35 NCOA1 is a transcriptional coactivator whose ablation confers susceptibility to diet-induced obesity.36 Interestingly, various fatty acids, but especially PUFAs, act as ligands for PPARα.