Following completion of the human genome project [6, 7], which was motivated in part by the quest to understand cancer [8], sequencing has been increasingly used to characterize parts of cancer genomes, expanding from PCR-based and Sanger sequencing of key cancer genes or families (e.g. all protein kinases) [9–11] to next-generation sequencing (NGS)-based technologies. Here, WEE1 is linked to cancer.