CP and malaria: Using the discontinuous risk interval analysis, PWP-CP, AG-CP, and the Shared gamma frailty models provided larger treatment effect on malaria episodes compared to GEE for the patients treated with AS + AQ or AS + SP as compared to the AL arm; RRs were: 0.75 (95% CI (Confidence Interval): 0.62-0.89), 0.74 (95% CI: 0.62-0.88) respectively for AG-CP model, 0.76 (95% CI: 0.64-0.89), 0.74 (95% CI: 0.62-0.87) for the Shared gamma frailty model and 1.02 (0.93-1.11), 0.93 (0.87-0.99) for GEE model (Table 2).