For example, necrosis caused by hepatic and cerebral ischemia/reperfusion is reduced by inhibition of Bax, and the effect is even stronger than that caused by inhibition of initial apoptotic signal, suggesting Bax plays an important role to promote necrotic cell death under this context (Ben-Ari et al., 2007; Hetz et al., 2005). Here, BAX is linked to Cerebral ischemia.