Previous studies found that CuE (10 μM) increased the expression of cyclin-dependent kinase inhibitors p21 and p27 in MDA-MB-231 cells [6], and that CuE (0.5–1 μM) likewise up-regulated the expression of p53 and p21 proteins in the bladder cancer cell line T24 [7]. Here, TP53 is linked to urinary bladder cancer.