For example, in the bladder cancer cell line T24, CuE administered at 0.5–1 μM induced apoptosis and triggered up-regulation of Fas/CD95, truncated BID (t-BID), apoptosis-inducing factor (AIF), and sequential activation of caspase-8, caspase-9, and caspase-3 [7]. Here, CASP8 is linked to urinary bladder carcinoma.