Among the immunosuppressive components, are CD11b+ Gr-1+ myeloid derived suppressor cells (MDSCs), which mediate tumor immunosuppression primarily through inducible nitric oxide synthase (iNOS) and arginase 1 (ARG1), leading to T cell apoptosis and depleting nutrients essential for T cell functioning, respectively [6], [7]. This evidence concerns the gene NOS2 and neoplasm.