Zhang et al. had reported significant expression of TRPV1 in 3T3-L1 preadipocytes and adipocytes (less than preadipocytes) from obese (ob/ob and db/db) mice and humans suggesting the functional role of TRPV1 in obesity and adipogenesis [3]. The gene discussed is TRPV1; the disease is obesity due to melanocortin 4 receptor deficiency.