As a key pro-metastatic target gene of Gli1 in pancreatic cancer it must have the following characteristics: First, there are effective Gli1 cis-acting elements in its gene sequence; Second, its transcription was regulated positively by Gli1; Third, it was upregulated in the majority of pancreatic cancer tissues and its expression level was positively correlated with Hh signaling; Fourth, its must be a key pro-metastatic functional factor. The gene discussed is GLI1; the disease is familial pancreatic carcinoma.