MAPT and Alzheimer disease: In exploratory reverse stepwise analyses, TFF3 was significantly associated with rate of decline in all three measures (Table 3), with an effect both independent from and at least as great as CSF t-tau, which as expected, also (unadjusted) predicted all three measures of neurodegeneration.27 The effect of TFF3 persisted even once baseline p-tau, age, sex and APOE4 status had been accounted for (Table 3), and was still associated with rate of hippocampal atrophy even once clinical diagnosis (for example, control/MCI/AD) had been accounted for.