In exploratory reverse stepwise models that included only those variables showing FDR significant associations in the initial analyses (Table 3), lower levels of TFF3 were associated with higher rates of whole brain atrophy, ventricular expansion and hippocampal atrophy, even when, p-tau, age, APOE status and sex were included in the model. The gene discussed is TFF3; the disease is hippocampal atrophy.