While numbers with a minor allele were too small for anything more than an exploratory analysis, the observation that genotype at the rs7280100, a candidate locus associated with TFF3, is intriguing, and if replicated in independent samples, suggests that CSF TFF3 and/or the rs7280100 genotype may both help predict the rate of neurodegeneration in individuals with amyloid pathology; and that elucidating the function of TFF3 in the central nervous system may provide insights into mechanisms influencing neurodegeneration in the presence of brain amyloidosis. The gene discussed is TFF3; the disease is amyloidosis.