For those analytes that were FDR significant in Table 2, the area under the ROC curve for detecting between AD and control groups were 0.59 (95% confidence interval=0.50, 0.69; CgA), 0.55 (0.45, 0.64; CysC), 0.55 (0.45, 0.65; TFF3) and 0.61 (0.52, 0.70; VEGF). The gene discussed is CGA; the disease is Alzheimer disease.