SPI1 and acute myeloid leukemia: As we revealed inverse correlations between MT1G and PU.1 expression in AML patients [12], and we also previously reported that PU.1 expression was inversely correlated with the tyrosine kinase receptor FLT3[13], and that strong expression of wild-type FLT3 was an unfavorable prognostic factor for overall survival [41], [42].