In the case of SSADH deficiency (SSADH), the KGD may work through restitution of GABAergic neurotransmission (36), although the use of KGD in SSADHD has been strongly argued until more research is performed to test its potential detrimental effects in humans (110). The gene discussed is ALDH5A1; the disease is succinic semialdehyde dehydrogenase deficiency.