In mouse models of ASD [i.e., Rett syndrome (56), BTBR model (57), and succinate semialdehyde dehydrogenase (SSADH) deficiency (36)], the use of the KGD has improved behavioral abnormalities (increased sociability and decreased self-directed repetitive behavior) and/or decreased the number of seizures, normalized ataxia, and increased lifespan of mutant mice. This evidence concerns the gene ALDH5A1 and atypical Rett syndrome.