Myeloid-derived suppressor cells down-modulate naïve CD4+ and CD8+ T lymphocyte trafficking and re-circulation (153), inhibit CD8+ T cell tumor and tumor-draining lymph node infiltration (154), suppress NK cells (155, 156) and promote the conversion of naive CD4+ T cells into induced Tregs (157–159). This evidence concerns the gene CD8A and neoplasm.