Interestingly, many tumor-derived soluble factors, like VEGF (116), adenosine (117), PGE2 (118), and TGFβ (119), which are crucial for EC activation, migration, and functionality, are also able to mediate inhibitory effects on DC activation, resulting in T cell suppression and induction of Tregs. This evidence concerns the gene TGFB1 and neoplasm.