PARK7 and Parkinson disease: For example, it was recently shown that trichostatin A selectively rescues mitochondrial fragmentation and cell death induced by MPP+ in human neuroblastoma cells (Zhu et al., 2014), and that sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of PD (St Laurent et al., 2013), alleviates cognitive deficits in a rat model of PD in the pre-motor deficit stage (Rane et al., 2012), and up-regulates DJ-1 protein expression and protects neurons in cell cultures and mouse models against MPP+ toxicity (Zhou et al., 2011).