Patients with T2D have increased glucagon secretion that exaggerates the disease state, and it is suggested that dysfunctional glucagon is due to impaired intrinsic glucose regulation (Rorsman et al., 2008) and/or loss of the characteristic phasic relationship between insulin and glucagon secretion (Gylfe and Gilon, 2014). The gene discussed is INS; the disease is type 2 diabetes mellitus.