KCNQ1 and type 2 diabetes mellitus: On the contrary, KCNQ1OT1 transcript levels have been shown to be significantly elevated in T2D islets (where SNP genotype was not determined; Morán et al., 2012), which parallels an overall decrease in methylation at several tested CpGs near the KCNQ1 gene (Dayeh et al., 2014).