The FMR1 premutation is present in about 11% of familial POF cases and about 3% of sporadic POF cases (Marozzi et al., 2000; Murray et al., 2000; Bussani et al., 2004), although a recent report from the United Kingdom suggests that only 2% of POF cases have a premutation (Murray et al., 2014). This evidence concerns the gene FMR1 and premature menopause.