Human monocytic THP-1 cells overexpressing a mutant variant of NLRP3 bearing the Q705K SNP have been reported to greatly respond to the inflammasome agonist alum and to trigger the production of IL-1β and IL-18, implying that overt NLRP3 activation could be detrimental for certain types of cancer (208). The gene discussed is NLRP3; the disease is cancer.