Overnutrition-associated IL-1 is implicated in pancreatic beta cell loss in T2D, atherogenesis in heart disease and stroke, and neurodegeneration in Alzheimer’s disease but, in general, IL-1 is a critical effector of sickness symptoms that include loss of appetite, locomotion, and social/environmental engagement (19). Here, IL1A is linked to early-onset autosomal dominant Alzheimer disease.