IGF1R and neoplasm: Several other tumor biomarkers, such as p53, mammalian target of rapamycin (mTOR), c-MET, insulin-like growth factor 1 receptor (IGF-1R), histone MacroH2A1 (7), and heat shock proteins (HSP) (8) including HSP70 are frequently up-regulated in tumor biopsies of HCC patients.