In fact, as brain GLP-1 has been increasingly suggested to be neuroprotective, it is possible that the modulation of its specific receptor may represent a promising strategy against neurodegeneration/death and memory and cognition impairment, i.e., it may constitute a putative pharmacological target against age- and/or T2D-related neurodegenerative diseases, including AD. Here, GLP1R is linked to Alzheimer disease.