INS and Alzheimer disease: However, Ho et al. reported that both diet-induced insulin resistance and a hyperinsulinemic state in an AD-like model was associated with lower IDE levels and Aβ accumulation (33), whereas Pedersen et al. showed that rosiglitazone administration (an insulin sensitizer) improved learning and memory and simultaneously reduced Aβ1–42 levels (the main pathological form of Aβ in brain tissues) (34).