Nevertheless, in 2005, Dormandy et al. reported that TZDs downregulated in vitro Aβ deposition, whereas Neumann et al. (93) observed that troglitazone reduces tau protein phosphorylation at serines 202 and 396/404 (known to be phosphorylated in early and later stages in AD, respectively, as well as in other neurodegenerative pathologies) (Figure 1). This evidence concerns the gene MAPT and Alzheimer disease.