Accumulated evidence indicated that IDE has also been linked to the etiology of some diseases, such as AD and type 2 diabetes mellitus (DM2) (3), associating the protein to a wide range of cellular processes, such as, varicella zoster virus infection, steroid receptor signaling, and IDE serves as a heat shock protein with implications in cell growth regulation and cancer progression (13, 20, 21). The gene discussed is IDE; the disease is Alzheimer disease.