Also, Pim-1 kinase phosphorylates heterochromatin protein-1 and nuclear mitotic apparatus protein (NuMA), which are crucial in cell division, while promoting cell proliferation in cancer and hematopoietic stem cells (Sun and Schatten, 2006) through the collaboration with c-Myc (Stewart et al., 1999; Zhang et al., 2007, 2008). Here, NUMA1 is linked to cancer.